William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Michael Sheen

William Masters

Lizzy Caplan

Virginia Johnson

Caitlin FitzGerald

Libby Masters

Annaleigh Ashford

Betty DiMello

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