Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

Guy Pearce

Leonard

Carrie-Anne Moss

Natalie

Joe Pantoliano

Teddy

Mark Boone Junior

Burt

Russ Fega

Waiter

Jorja Fox

Leonard's Wife

Stephen Tobolowsky

Sammy

Harriet Sansom Harris

Mrs. Jankis

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