Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Gary Oldman

Dr. Tyrone Brower

Armie Hammer

Jake Kelly

Evangeline Lilly

Claire Reimann

Greg Kinnear

Dean Talbot

Michelle Rodriguez

Supervisor Garrett

Luke Evans

Dr. Bill Simons

Lily-Rose Depp

Emmie Kelly

Guy Nadon

Mother

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