Maggie is an alluring free spirit who won't let anyone – or anything – tie her down. But she meets her match in Jamie, whose relentless and nearly infallible charm serves him well with the ladies and the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

Jake Gyllenhaal

Jamie Randall

Anne Hathaway

Maggie Murdock

Oliver Platt

Bruce Winston

Hank Azaria

Dr. Stan Knight

Josh Gad

Josh Randall

Gabriel Macht

Trey Hannigan

Judy Greer

Cindy

Jill Clayburgh

Nancy Randall

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